Product introduction：
Cas: 209216-23-9
Other names: entecavir hydrate, entecavir
MF: C12H17N5O4
Molecular Weight: 295.29448
Water: 5.8%—6.5%
Residue on ignition: ≤0.1％
Heavy metals: ≤20ppm
Assay: 98.0%--102..0%
Description: Entecavir powder cas 209216-23-9 is an antiviral drug with activity against hepatitis B viral polymerase. As Entecavir powder cas 209216-23-9 is an analogue of the nucleoside guanosine, it competes with the enzyme's usual substrate. This reduces the synthesis of viral DNA. Entecavir is therefore indicated when there is evidence of viral replication.
How it works: Entecavir powder cas 209216-23-9 is a reverse transcriptase inhibitor that works by preventing the hepatitis B virus from multiplying and thereby decreasing the amount of the virus in the body. However, it is important to note that entecavir is not a cure for HBV and it may not prevent damage to the liver or reduce the chances of developing liver cancer. In addition, Entecavir powder cas 209216-23-9 doesn't prevent the spread of HBV to others through the normal routes of transmission, including sexual contact or exposure to blood or bodily fluids.
Other chemical names: Entecavir hydrate/entecavir, Entecavir Monohydrate IsoMers, 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one monohydrate
Certificate of analysis
|
Items
|
Specifications
|
Results
|
|
Appearance
|
White to off-white powder
|
White powder
|
|
Identification
|
1)The IR absorption spectrum of the sample must be
concordant with entecavir
2) RT of the sample should match that of standardin assay
preparation
|
Conform
|
|
2) RT of the sample should match that of standard in assay
preparation
|
Conform
|
|
Water
|
5.8%—6.5%
|
6.1%
|
|
Optical rotation
|
+24.0°—+28.0°(DMF: Me OH=1:1 c=1%)
|
+27.0°
|
|
Residue on ignition
|
≤0.1%
|
0.07%
|
|
Heavy metals
|
≤20ppm
|
＜20ppm
|
|
Related substances
|
Total impurities ≤0.3%
|
0.06%
|
|
Any individual impurity≤0.1%
|
0.02%
|
|
Residual solvents
|
dichloromethane≤600ppm
methanol≤3000ppm
ethyl acetate≤5000ppm
toluene≤890ppm
|
not detected
200ppm
not detected
not detected
|
|
Assay
|
98.0%--102..0%
|
99.9%
|
|
Particle size
|
95% of the particles should be within 125um
|
Conform
|
