Product introduction:
CAS: 78755-81-4
MF: C15H14FN3O3
Molecular Weight: 303.29
Perform Standard: USP
Melting point: 198℃ to 202℃
Assay(On dried substance): 99.0-101.0%
Application:
1、 Flumazenil powder cas 78755-81-4 has been used as an antidote in the treatment of benzodiazepine overdoses
2、 Flumazenil powder cas 78755-81-4 is also sometimes used after surgery to reverse the sedative effects of benzodiazepines.
3、Flumazenil powder cas 78755-81-4 has been effectively used to treat overdoses of non-benzodiazepine hypnotics, such as zolpidem, zaleplon and zopiclone (also known as "Z-drugs").
4、Flumazenil powder cas 78755-81-4 is effective in reducing excessive daytime sleepiness while improving vigilance in primary hypersomnias, such as idiopathic hypersomnia.
5、Flumazenil powder cas 78755-81-4 has also been used in hepatic encephalopathy. It may have beneficial short‐term effects in people with cirrhosis, but there is no evidence for long-term benefits.
Other chemical names: RO 15-1788,FLUMAZENIL;RO 15-1788; RO15-1788,ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4h-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
Certificate of analysia
Items
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Specifications
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Test Results
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Appearance
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White to a class of white powder
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Conforms
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Identification
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The sample’S IR spectrum is according with spectrum of Flumazenil.
The retention time of the major peak Flumazenil in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation .
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Conforms
Conforms
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Melting point
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198℃ to 202℃
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199.6℃ to 200.7℃
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Related
substances
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Known impurities
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Impurity A: NMT 0.10%
Impurity B: NMT 0.2%
Impurity C: NMT 1.0%
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Not detected
0.03%
0.02%
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Individual unknown impurity
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NMT 0.10%
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0.02%
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Total impurities
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NMT 0.15%
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0.07%
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Loss on drying
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NMT 0.5%
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0.2%
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Sulphated ash
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NMT 0.1%
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0.05%
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Heavy metals
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NMT 20ppm
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5ppm
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Bacterial endotoxins ( for injection )
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NMT 0.56EU/mg
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Conforms
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Assay (On dried substance)
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99.0-101.0%
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99.93%
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Guarantees the nature time
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36 months
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Conclusion
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The test comply with the specification of USP32
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Conclusion: the product conforms to the above specifications.
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